The Role of VDR in the Regulation of the Vitamin D Receptor

VDR may be a key transcribing factor that regulates the vitamin D receptor (VDR) gene in response to at least one, 25-(OH)2D3 and retinoid X receptor (RXR). When bound to DNA, VDR interacts with vitamin D receptive elements (VDRE) in the aim for genes to regulate their term. The co-activators and co-repressors that content to these VDRE are not yet fully recognized but consist of ATPase-containing nucleosomal remodeling meats, chromatin histone enhancing enzymes, as well as the transcription element RNA polymerase II.

VDRE are present in the majority of vitamin D-responsive genes, which includes IL-2, osteocalcin, and alkaline phosphatase. The VDR is highly polyfunctional, as well as activity depend upon which abundance and activity of various proteins that interact with that.

Transcriptional control for the VDR gene includes the presence and activity of a number of enhancers, as well as debut ? initiation ? inauguration ? introduction of various epigenetic changes. During VDR expression, marketers are generally acetylated and ligand binding increases.

Genetic modifications in VDR are found naturally in the population and have been linked to disease risk. For example , polymorphisms of the VDR b allele have been found to be linked together with the development of diabetes and spinal tuberculosis.

Affected individuals may react less to pharmacologic dosage of 1, 25-(OH)2D3 than control people. Affected patients have elevated risks meant for autoimmune ailments, cancer, and autoimmunity-related disorders.

VDR has also been shown to effect the growth and expansion of T cells. Simply by regulating T cell receptor signaling, VDR-mediated PLC-g1 upregulation contributes to P cell priming. This process is important just for naive T cells to be able to produce the cytokine IL-2 and become triggered by antigen-induced T cell stimulation.


資料請求・お問合せ TEL.0532-38-0525

(電話 平日11:00~19:00受付)